Suppressing and activating effects of Nogo-B receptors in the pathogenesis of malignant solid tumors / 解剖学报

ABSTRACT

Nogo-B is a major family member of the reticulon protein family 4. It is widely expressed in the central nervous system and peripheral tissues. Studies have shown that Nogo-B binds to three different receptors; Nogo receptor-1 (NgRl), Nogo-B specific receptor (NgBR) and paired immunoglobulin like receptor B(PirB). These receptors play a dual role of suppression and promotion in angiogenesis, proliferation and apoptosis, invasion and migration, which are important events in tumor development and progression, through various post-receptor signaling pathways, including RhoA/Rho- associated coiled-coil contaning protein kinase (RhoA/ROCK), phosphatidylinositol 3-kinase/protein kinase B (PI3K/ Akt), adenosine 5-monophosphate-activated protein kinase α/liver X receptor α(AMPAa/LXRα), extracellular signal- regulated kinase (ERK), epithelial-mesenchymal transition (EMT), unfolded protein response (UPR) and so on. An in- depth understanding of the mechanisms by which Nogo-B receptors are involved in tumor pathogenesis will provide new insights into the development of drugs. Here, we will summarize the up-to-date researches on the basic structure and expression of Nogo-B/Nogo-B receptors and the suppressing/activating effects of post-receptor signaling pathways in the pathogenesis of malignant solid tumors.