Relationship Between Vitamin D Receptor Gene Polymorphisms and Risk of Ulcerative Colitis: A Meta-analysis / 胃肠病学

ABSTRACT

Background: Vitamin D receptor (VDR) is associated with the occurrence and development of ulcerative colitis (UC). The expression and function of VDR may be affected by its gene polymorphisms, and thus affecting the occurrence of UC. However, results of studies are still in controversary. Aims: To explore the relationship between VDR gene polymorphisms and UC. Methods: Studies on correlation of VDR gene (Apa, Bsm, Fok, Taq) polymorphisms with UC were retrieved from SinoMed, CNKI, Wanfang, VIP, Embase, PubMed, The Cochrane Library databases. Literatures were enrolled according to the inclusion and exclusion criteria, and the data were extracted. RevMan 5.3 was used to conducted meta-analysis. Results: A total of 11 studies involving 1 811 UC patients were included. Meta-analysis showed that VDR gene Fok polymorphism (FF + Ff vs. ff OR=0.67, 95% CI 0.49-0.92, P=0.01), allele (F vs. f OR=0.81, 95% CI 0.68-0.96, P=0.02) were significantly correlated with the susceptibility of UC. Among which, Fok polymorphism (FF+Ff vs. ff OR=0.59, 95% CI 0.37-0.94, P=0.03), allele (F vs. f OR=0.76, 95% CI 0.60-0.97, P=0.03) were significantly correlated with the susceptibility of UC in Asian, but not in Caucasian population (P>0.05). No significant association was observed between Apa, Bsm, or Taq polymorphisms and UC (P>0.05). Conclusions: Existing evidence shows that VDR gene Fok polymorphism might contribute to UC susceptibility, however, Apa, Bsm, and Taq polymorphisms might not be significantly correlated with UC.