Clinical Value of Exosome Circular RNA in Early Screening of Colorectal Cancer / 胃肠病学

ABSTRACT

Exosomes are nanoscale membranous vesicles that can be released by any type of cells. They contain proteins, lipids and nucleic acids, and are released from multiple vesicles after fusion with the cell membrane. As a signal transmitting molecule, exosomes can deliver bioinformation-containing contents to target cells and play a specific role. Circular RNA (circRNA) is a new type of long non-coding RNA. Since circRNA is a closed circular structure RNA without a 5'cap and a 3' tail, it is not affected by exonuclease and exists stably. Recently, more and more studies have shown that circRNA is closely related to the occurrence, development and prognosis of colorectal cancer (CRC). Detection of serum circRNA may have important clinical value for early screening of CRC. This article reviewed the clinical value of exosome circRNA in early screening of CRC.