Thoracic metastasis in advanced ovarian cancer: comparison between computed tomography and video-assisted thoracic surgery / 부인종양
Journal of Gynecologic Oncology
;
: 260-268, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-101753
ABSTRACT
OBJECTIVE:
To determine which computed tomography (CT) imaging features predict pleural malignancy in patients with advanced epithelial ovarian carcinoma (EOC) using video-assisted thoracic surgery (VATS), pathology, and cytology findings as the reference standard.METHODS:
This retrospective study included 44 patients with International Federation of Obstetrics and Gynecology (FIGO) stage III or IV primary or recurrent EOC who had chest CT < or =30 days before VATS. Two radiologists independently reviewed the CT studies and recorded the presence and size of pleural effusions and of ascites; pleural nodules, thickening, enhancement, subdiaphragmatic tumour deposits and supradiaphragmatic, mediastinal, hilar, and retroperitoneal adenopathy; and peritoneal seeding. VATS, pathology, and cytology findings constituted the reference standard.RESULTS:
In 26/44 (59%) patients, pleural biopsies were malignant. Only the size of left-sided pleural effusion (reader 1 rho=-0.39, p=0.01; reader 2 rho=-0.37, p=0.01) and presence of ascites (reader 1 rho=-0.33, p=0.03; reader 2 rho=-0.35, p=0.03) were significantly associated with solid pleural metastasis. Pleural fluid cytology was malignant in 26/35 (74%) patients. Only the presence (p=0.03 for both readers) and size (reader 1 rho=0.34, p=0.04; reader 2 rho=0.33, p=0.06) of right-sided pleural effusion were associated with malignant pleural effusion. Interobserver agreement was substantial (kappa=0.78) for effusion size and moderate (kappa=0.46) for presence of solid pleural disease. No other CT features were associated with malignancy at biopsy or cytology.CONCLUSION:
In patients with advanced EOC, ascites and left-sided pleural effusion size were associated with solid pleural metastasis, while the presence and size of right-sided effusion were associated with malignant pleural effusion. No other CT features evaluated were associated with pleural malignancy.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias Ováricas
/
Enfermedades Pleurales
/
Derrame Pleural
/
Neoplasias Pleurales
/
Ascitis
/
Semillas
/
Tórax
/
Biopsia
/
Estudios Retrospectivos
/
Derrame Pleural Maligno
Tipo de estudio:
Estudio observacional
Límite:
Humanos
Idioma:
Inglés
Revista:
Journal of Gynecologic Oncology
Año:
2011
Tipo del documento:
Artículo
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