Correlation between hypoxia and the oxygen sensing pathway in acute myeloid leukemia cells / 国际肿瘤学杂志

ABSTRACT

Hypoxia is one of the significant characteristics of the microenvironment of malignant tumors in the blood system. Hypoxic microenvironment can promote the metastasis and infiltration of tumor cells, which is one of the key factors leading to treatment tolerance, and also an important factor for resistance against tumor immune response. In acute myeloid leukemia (AML), the cellular oxygen sensing pathway is an important signaling transduction pathway that participates in the cell's response to hypoxic environments and can regulate biological processes such as metabolism, growth, and survival. Starting from how hypoxia affects the oxygen sensing pathway of leukemia cells, and targeting the cell adaptation mechanism induced by hypoxia, exploring new directions for targeted treatment of hematological malignancies in hypoxic environments can provide new ideas and theoretical support for the treatment of AML.