Understanding of molecular pathogenesis and genetic markers in colorectal cancer / 대한내과학회지
Korean Journal of Medicine
;
: 113-118, 2010.
Artículo
en Coreano
| WPRIM
| ID: wpr-102122
ABSTRACT
Colorectal cancers results from the progressive accumulation of genetic and epigenetic alterations that lead to cellular transformation and tumor progression. Genomic instability, including chromosomal translocations and microsatellite instability, plays a role in acquisition of enough mutations for malignant transformation. In addition, epigenetic silencing is an important mechanism in the evolution of a subgroup of colorectal cancers. These genetic and epigenetic changes causes activation of oncogene pathway (APC, KRAS) and inactivation of tumor-suppressor pathway (p53, TGF-beta). Recent advance in colorectal carcinogenensis leads to development of molecular markers for early detection and predictive and prognostic markers.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Oncogenes
/
Translocación Genética
/
Neoplasias Colorrectales
/
Marcadores Genéticos
/
Inestabilidad Genómica
/
Inestabilidad de Microsatélites
/
Epigenómica
Tipo de estudio:
Estudio de etiología
/
Estudio de tamizaje
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Año:
2010
Tipo del documento:
Artículo
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