Correlation between inflammatory factors and serum ICAM-1 expression in patients with diabetic foot ulcer / 中国糖尿病杂志

ABSTRACT

Objective To investigate the expression of intercellular adhesion molecule 1(ICAM-1)in patients with diabetic foot ulcer(DFU)and its correlation with inflammatory cytokines.Methods A total of 152 patients with DFU(DFU group)and 133 patients with type 2 diabetes mellitus(T2DM group)admitted to our hospital from January 2021 to December 2022 were selected as the study group.120 healthy people matched in age and sex were set as the control group(NC group).Pearson correlation analysis was applied to analyze the correlation between serum ICAM-1 and wagner grade in DFU patients.Results HbA1c,TG,ICAM-1,C-RP,TNF-α,IL-6,IL-18,IL-1β in NC,T2DM and DFU groups gradually increased,but HDL-C gradually decreased(P＜0.05).Pearson correlation analysis showed that serum ICAM-1 was positively associated with C-RP and TNF-α,IL-6,IL-18,IL-1β and wagner grading in DFU patients(P＜0.01).Logistic regression analysis showed that ICAM-1,C-RP,HbA1c and IL-18 were the influencing factors of DFU.Conclusion High levels of serum ICAM-1 in DFU patients are closely related to inflammatory factors and Wagner grading,which helps to identify the severity of the condition.