Periostin level changes in elderly patients with chronic obstructive pulmonary disease and their correlation with blood eosinophils and lung function / 中华老年医学杂志

ABSTRACT

Objective:To examine changes in serum periostin in elderly patients with chronic obstructive pulmonary disease(COPD)and their correlation with blood eosinophils(EOS)and lung function, and to explore whether serum periostin can be used as a biomarker for COPD.Methods:Case-control study, a total of 128 hospitalized elderly patients with COPD were enrolled in the COPD group, and 60 healthy elderly adults receiving physical check-ups were included in the control group between December 2018 and May 2021.Serum periostin, blood EOS, eosinophil percentage(EOS%)and lung function were measured for all participants.In addition, serum periostin in the COPD group was also measured after treatment.Differences in serum periostin, EOS, EOS% and the predicted percentage value of forced expiratory volume in one second(FEV1%pred)as a measure for lung function were compared between the COPD group and the control group, and differences in serum periostin in the COPD group before and after treatment were also compared.Patients in the COPD group were further divided into a mild subgroup, a moderate subgroup and a severe subgroup, and differences in values of the parameters were compared between the subgroups.Multiple linear regression was used to analyze the correlation of serum periostin with blood EOS and FEV1%pred; the correlation between periostin and COPD was analyzed by binary Logistic regression; the correlation between periostin and COPD severity was analyzed by ordered multinomial Logistic regression.Results:Serum periostin, EOS and EOS% in the COPD group were higher than in the control group, FEV1%pred was lower than in the control group(all P<0.05), and post-treatment serum periostin in the COPD group was lower than pre-treatment levels[(103.47±9.58)mg/L vs.(105.20±9.45)mg/L, t=2.830, P=0.005)]. Serum periostin, EOS and EOS% in the moderate and severe subgroups were higher than in the mild subgroup, and their levels in the severe subgroup were higher than in the moderate subgroup.FEVl%pred in the moderate and severe subgroups was lower than in the mild subgroup, while FEVl%pred in the severe subgroup was lower than in the moderate subgroup(all P<0.05). Multiple linear regression analysis showed that serum periostin was positively correlated with blood EOS( β=33.728, P=0.002)and negatively correlated with FEVl%pred( β=-0.208, P=0.001). Logistic regression analysis showed that high serum periostin was a risk factor for COPD( OR=1.079, 95% CI: 1.019-1.143, P=0.009)and also a risk factor for the severity of COPD( OR=1.097, 95% CI: 1.015-1.186, P=0.020). Conclusions:High serum periostin increases the risk of occurrence and aggravation of COPD, serum periostin correlates with blood EOS and lung function and has the potential to become one of the biomarkers for COPD.