Effect of Preconditioning by Low-Flow Perfusion on Cardioprotection
Korean Circulation Journal
;
: 1252-1260, 2001.
Artículo
en Coreano
| WPRIM
| ID: wpr-102906
ABSTRACT
BACKGROUND AND OBJECTIVES:
Recent reports suggest that brief periods of low-flow ischemia (lf Isc) and reperfusion (R) before prolonged Isc mimic ischemic preconditioning (IPC) in murine hearts, probably by a preservation of high energy phosphates. MATERIALS ANDMETHODS:
In order to test this hypothesis, Langendorff-perfused isolated rabbit hearts were subjected to 45 min lf Isc (5% of baseline perfusion flow) with lf IPC or not, followed by 120 min R. lf IPC was induced by a single episode of 5 min lf Isc and 10 min R. These were compared with IPC hearts by 5 min no-flow Isc and 10 min R.RESULTS:
lf IPC as well as IPC enhanced post-ischemic functional recovery although IPC did not reduce infarct size (Isc control, 37.5+/-3.1, IPC, 16.2+/-1.5, lf Isc, 43.0+/-0.7, and lf IPC, 40.4+/-1.0% of the left ventricle). Myocardial ATP hydrolysis and lactate production during the preischemic, ischemic, and reperfusion periods were not differ between the experimental groups.CONCLUSION:
These results suggest that a brief period of lf Isc could not precondition the rabbit heart and the energy metabolism hypothesis may not be a universal mechanism for the cardioprotective effect of IPC.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Perfusión
/
Fosfatos
/
Reperfusión
/
Adenosina Trifosfato
/
Ácido Láctico
/
Precondicionamiento Isquémico
/
Metabolismo Energético
/
Corazón
/
Hidrólisis
/
Isquemia
Idioma:
Coreano
Revista:
Korean Circulation Journal
Año:
2001
Tipo del documento:
Artículo
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