Research progress of the roles of tumor-associated macrophages in gallbladder cancer / 肿瘤

ABSTRACT

Gallbladder cancer(GBC)is a common malignancy of the biliary system with a poor diagnosis.The 5-year survival rate for patients with advanced GBC is less than 10％.Surgery is the only effective treatment for this disease.Tumor microenvironment(TME)plays an important role in GBC tumorigenesis,progression and prognosis.Tumor-associated macrophages(TAMs)are among the most abundant immune cells infiltrating the TME and are present in all stages of GBC progression.This paper has summarized the dynamic phenotypic transformation that macrophages undergo during GBC progression,discussed the impact that TAMs bring to GBC progression and the therapeutic potential of TAM-targeted strategies,and proposed the possible ways in which TAM are involved in the mechanism of GBC progression and are linked to the construction of the immunosuppressive TME.A generalization and analysis of the biological properties of TAM and their roles in GBC was carried out in the hope to provide reference for the development and innovation of GBC therapies.