Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo
Annals of Dermatology
;
: 6-11, 2009.
Artículo
en Inglés
| WPRIM
| ID: wpr-103074
ABSTRACT
BACKGROUND:
No studies have yet been undertaken to determine the effect of aloe gel on the clinical signs and biochemical changes of aging skin.OBJECTIVE:
We wanted to determine whether dietary aloe vera gel has anti-aging properties on the skin.METHODS:
Thirty healthy female subjects over the age of 45 were recruited and they received 2 different doses (low-dose 1,200 mg/d, high-dose 3,600 mg/d) of aloe vera gel supplementation for 90 days. Their baseline status was used as a control. At baseline and at completion of the study, facial wrinkles were measured using a skin replica, and facial elasticity was measured by an in vivo suction skin elasticity meter. Skin samples were taken before and after aloe intake to compare the type I procollagen and matrix metalloproteinase 1 (MMP-1) mRNA levels by performing real-time RT-PCR.RESULTS:
After aloe gel intake, the facial wrinkles improved significantly (p<0.05) in both groups, and facial elasticity improved in the lower-dose group. In the photoprotected skin, the type I procollagen mRNA levels were increased in both groups, albeit without significance; the MMP-1 mRNA levels were significantly decreased in the higher-dose group. Type I procollagen immunostaining was substantially increased throughout the dermis in both groups.CONCLUSION:
Aloe gel significantly improves wrinkles and elasticity in photoaged human skin, with an increase in collagen production in the photoprotected skin and a decrease in the collagen- degrading MMP-1 gene expression. However, no dose- response relationship was found between the low-dose and high-dose groups.
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Piel
/
Succión
/
Envejecimiento
/
ARN Mensajero
/
Expresión Génica
/
Colágeno
/
Procolágeno
/
Dermis
/
Metaloproteinasa 1 de la Matriz
/
Colágeno Tipo I
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Annals of Dermatology
Año:
2009
Tipo del documento:
Artículo
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