Event-related potential P300 and cognitive function in patients with chronic insomnia disorder / 中风与神经疾病杂志

ABSTRACT

@#Objective To investigate the difference in event-related potential P300 between the patients with chronic insomnia disorder and the health population. Methods P300 was collected and analyzed for 26 healthy volunteers and 26 patients with chronic insomnia disorder，and 20 electrode caps were worn according to the standard position of international 10~20 system for EEG scalp recording. The auditory Oddball model and MATLAB software were used for data analysis，and the amplitude and latency of P300 were compared between the two groups. Results Compared with the healthy volunteers，the patients with chronic insomnia disorder had lower amplitudes of Fz，Cz，and Pz electrodes，with significant differences at Fz and Pz electrodes (P<0.05). There was an increase in latency without statistical significance (P>0.05). Conclusion There is a difference in P300 between healthy volunteers and patients with chronic insomnia disorder，which may be associated with the cognitive function of patients with chronic insomnia disorder.