Anti-glutamate decarboxylase 65 antibody stiff-person syndrome and autoimmune polyendocrinopathy syndrome type Ⅱ:a case report and literature review / 中风与神经疾病杂志

ABSTRACT

@#Objective To share a case of anti-glutamate decarboxylase 65 antibody stiff-person syndrome and autoimmune polyendocrinopathy syndrome type Ⅱ,to improve clinicians' understanding of this disease. Methods The clinical data of a 51-year-old woman who was admitted to the affiliated hospital of a Neurology Institute in Anhui Province in 2022 was retrospectively analyzed,and the relevant literature was reviewed. Results Patients' clinical to repeatedly lumbago,lumbar abdomen and the stiffness of lower limbs with unable to characteristics of early misdiagnosed as separate conversion disorder,after the inspection found that serum and cerebrospinal fluid resistance to glutamic acid decarboxylase antibody positive 65,thyroglobulin antibody and higher peroxidase antibody degrees,fasting and postprandial 2 hours blood sugar,glycosylated hemoglobin,Neuroelectrophysiology showed that the continuous motor unit potential was mainly distributed by body axis muscles in the resting state. The patient was diagnosed as anti-glutamic acid decarboxylase 65 antibody SPS and APS-Ⅱ (Hashimoto's thyroiditis,type 1 diabetes mellitus),and the condition improved after immunotherapy and symptomatic treatment. Conclusion Although anti-glutamate decarboxylase 65 antibody SPS complicated with APS-Ⅱ has certain clinical specificity,it is easy to be misdiagnosed and missed because of its rarity,especially in the early course of disease.