Use of progesterone supplement therapy for prevention of preterm birth: review of literatures
Obstetrics & Gynecology Science
; : 405-420, 2017.
Article
en En
| WPRIM
| ID: wpr-103249
Biblioteca responsable:
WPRO
ABSTRACT
Preterm birth (PTB) is one of the most common complications during pregnancy and it primarily accounts for neonatal mortality and numerous morbidities including long-term sequelae including cerebral palsy and developmental disability. The most effective treatment of PTB is prediction and prevention of its risks. Risk factors of PTB include history of PTB, short cervical length (CL), multiple pregnancies, ethnicity, smoking, uterine anomaly and history of curettage or cervical conization. Among these risk factors, history of PTB, and short CL are the most important predictive factors. Progesterone supplement therapy is one of the few proven effective methods to prevent PTB in women with history of spontaneous PTB and in women with short CL. There are 2 types of progesterone therapy currently used for prevention of PTB: weekly intramuscular injection of 17-alpha hydroxyprogesterone caproate and daily administration of natural micronized progesterone vaginal gel, vaginal suppository, or oral capsule. However, the efficacy of progesterone therapy to prevent PTB may vary depending on the administration route, form, dose of progesterone and indications for the treatment. This review aims to summarize the efficacy and safety of progesterone supplement therapy on prevention of PTB according to different indication, type, route, and dose of progesterone, based on the results of recent randomized trials and meta-analysis.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Embarazo Múltiple
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Progesterona
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Humo
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Supositorios
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Cremas, Espumas y Geles Vaginales
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Fumar
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Parálisis Cerebral
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Discapacidades del Desarrollo
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Mortalidad Infantil
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Factores de Riesgo
Tipo de estudio:
Clinical_trials
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Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Female
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Humans
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Infant
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Pregnancy
Idioma:
En
Revista:
Obstetrics & Gynecology Science
Año:
2017
Tipo del documento:
Article