The Effect of Ophthalmic Solution and Ointment on Healing of Experimental Wound of Rabbit Corneal Epithelium

ABSTRACT

The effect of 1% atropine solution and 1% atropine ointment on healing of corneal epithelium in 20 rabbits was studied. Corneal epithelium was removed by #15 blade in central area of 7mm in diameter under topical anesthesia with 0.5% pontocaine. 1% atropine solution was applied three times daily to Rt. eyes, and 1% atropine ointment to Lt. eyes. Progress of epithelial healing was observed by fluorescent staining of the wound. At the end of 24 hours, fluorescent staining area was 46.90% in average for Rt. eyes, and 51.90% in average for Lt. eyes. At the end of 48 hours, it was 7.83% for Rt. eyes, and 11.0% for Lt. eyes. At the end of 72 hours, All of Rt. eyes did not stain, but 2 of 10 Lt. eyes were faintly stained. Difference between ophthalmic solution and ointment on the effect of corneal epithelial healing was not significant.