Role and mechanism of Schwann cells in peripheral nerve regeneration / 中华神经医学杂志

ABSTRACT

Recent studies have shown that Schwann cells (SCs) can effectively promote peripheral nerve regeneration under physical modulation of mechanical retraction, electricity, magnetism, light, and extracorporeal shock waves, whose neural signaling pathways involve Janus kinase/signal transduction and transcriptional activator (JAK-STAT) pathway, mitogen-activated protein kinase (MAPK) pathway, Notch pathway, and neuregulin 1 (NRG1) pathway. In this paper, we summarize the role and mechanism of SCs in peripheral nerve regeneration, as well as the therapeutic strategies based on SCs to promote peripheral nerve repair in recent years, aiming to provide references for clinical treatment of peripheral neuropathy.