The clinical effects of rabeprazole and omeprazole in treatment of reflux esophagitis / 中国现代医生

ABSTRACT

Objective To compare the clinical effects of rabeprazole and omeprazole in treatment of reflux esophagitis. Methods A total of 84 cases of patients with reflux esophagitis were randomly divided into control group and research group. The control group were treated by omeprazole, the research group were treated by rabeprazole. The clinical effects, endoscopic clinical effects, adverse reactions, number of reflux, total time were compared. Results The effective rate of the research group(92.86%) was higher than the control group(71.43%)(P<0.05);The effective rate of the en-doscopic clinical effects for the research group (95.24%) was higher than the control group (69.05%)(P<0.05);The symptoms of heartburn scores for the two groups posttreatment were better than prior treatment (P<0.05); The reflux symptom scores for the two groups posttreatment were better than prior treatment(P<0.05);The number of reflux in 24 h with pH<4 of the research group (10.26±2.41) was lower than the control group (25.81±4.32)(P<0.05);The time of the research group(1.02±0.23)h was lower than the control group(3.04±1.20)h(P<0.05). Conclusion It has rapid on-set, long the effective time, clinical effect with high reliability, good safety and good clinical effect for the patients with reflux esophagitis treated by rabeprazole. It is valuable in clinical application.