Duodenal Implications in the Pathophysiology of Functional Dyspepsia
Journal of Neurogastroenterology and Motility
;
: 251-257, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-103880
ABSTRACT
Functional dyspepsia (FD) is a heterogeneous disorder associated with diverse pathophysiologic mechanisms. Studies have shown duodenal implications in the pathophysiology of FD. Duodenal hypersensitivity to acid, increased duodenal acid exposure, and abnormal responses to duodenal lipids or released cholecystokinin have been observed in patients with FD. Moreover, there is evidence indicating duodenal immune activation in FD. Alterations in the number of duodenal eosinophils or intraepithelial lymphocytes have been reported in a subset of FD patients, particularly in patients with post-infectious FD. Whether these abnormalities in the duodenum play a crucial role in the generation of dyspeptic symptoms needs to be elucidated. Further investigations on the relationship between duodenal abnormalities and well-known pathophysiologic mechanisms of FD are required. Furthermore, the causative factors related to the development of duodenal abnormalities in FD warrant further study.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Colecistoquinina
/
Linfocitos
/
Duodeno
/
Dispepsia
/
Eosinofilia
/
Eosinófilos
/
Hipersensibilidad
Límite:
Humanos
Idioma:
Inglés
Revista:
Journal of Neurogastroenterology and Motility
Año:
2010
Tipo del documento:
Artículo
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