The Effects of cerebrospinal fluid AMPA receptor levels on the clinical efficacy of lamotrigine in the treatment of epilepsy / 中风与神经疾病杂志

ABSTRACT

@#Objective　To explore the effects of cerebrospinal fluid AMPA receptor levels on the clinical efficacy of lamotrigine in the treatment of epilepsy. Methods　The 70 cases of epilepsy in our hospital were diagnosed and selected in this study from December 2017 to October 2019；The AMPA receptor content of patients in cerebrospinal fluid were determined by enzyme linked immunosorbent assay；The patients were paired into high AMPA group （n=34） and low AMPA group （n=36） according to the median value at 4.08 ng/ml. Clinical efficacy and the incidence of adverse reactions were compared between two groups. Results　Before treatment，there was no significant difference in seizure frequency between the two groups （P>0.05）；After treatment for 6 months and 12 months，the seizure frequencies of the two groups were gradually reduced （P<0.05）；Moreover，the number of seizures in the low AMPA group were significantly less than those in the high AMPA group （P<0.05）；The response rate of high AMPA group was 79.41%，which was significantly lower than that in the low group AMPA （χ2=6.055，P=0.048）；The improvement on the efficiency of electroencephalogram in the high AMPA group was 67.65%，which was significantly lower than that in the low AMPA group （χ2=4.686，P=0.030）；However，there was no significant on the incidence of adverse reactions between two groups （χ2=0.202，P=0.653）. Conclusion　AMPA receptor plays an important role in the development of epilepsy and the low AMPA receptor level patients were more efficacies to the treatment of lamotrigine.