Apolipoprotein E4: A Risk Factor for Successful Cognitive Aging
Dementia and Neurocognitive Disorders
;
: 61-67, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-105260
ABSTRACT
Apolipoprotein E is a plasma protein that has an important role in transport and metabolism of lipids in serum as well as central nervous system. Among the 3 common alleles, the ε2 allele has the most stable structure followed by ε3 and ε4 in order. There is evidence for a deleterious role of ε4 allele by atherosclerosis and amyloid beta accumulation in brain and body. The presence and gene dose of ε4 allele are risk factors for late-onset Alzheimer's disease. Apolipoprotein E ε4 may have a role in the pathology of amyloid beta and tau and it has a strong relationship with the early onset of late-onset Alzheimer's disease. However, early-onset Alzheimer's disease has a weaker relationship with ε4 allele of apolipoprotein E.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Apolipoproteínas
/
Plasma
/
Encéfalo
/
Sistema Nervioso Central
/
Factores de Riesgo
/
Alelos
/
Aterosclerosis
/
Apolipoproteína E4
/
Enfermedad de Alzheimer
Tipo de estudio:
Estudio de etiología
/
Factores de riesgo
Idioma:
Inglés
Revista:
Dementia and Neurocognitive Disorders
Año:
2016
Tipo del documento:
Artículo
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