Comparison of Plasma Concentrations of Posaconazole with the Oral Suspension and Tablet in Korean Patients with Hematologic Malignancies / 감염과화학요법
Infection and Chemotherapy
;
: 135-139, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-105544
ABSTRACT
The posaconazole tablet formulation was developed to have improved bioavailability compared to the oral suspension. Here, we compared posaconazole plasma concentration (PPC) with the posaconazole oral suspension versus the tablet in Korean patients undergoing remission induction chemotherapy for hematologic malignancies. PPC was measured at 3, 8, and 15 days of treatment with the oral suspension (174 patients) or the tablet (40 patients). At all time-points, mean PPC was significantly higher with the tablet compared to the oral suspension. Our findings suggest that posaconazole tablets generate an optimal PPC earlier and in more patients than the oral suspension among Korean patients.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plasma
/
Comprimidos
/
Inducción de Remisión
/
Disponibilidad Biológica
/
Neoplasias Hematológicas
/
Formas de Dosificación
/
Quimioterapia
/
Antifúngicos
Límite:
Humanos
Idioma:
Inglés
Revista:
Infection and Chemotherapy
Año:
2017
Tipo del documento:
Artículo
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