The mechanism of phospholipase C-gamma1 regulation
Experimental & Molecular Medicine
;
: 101-109, 2000.
Artículo
en Inglés
| WPRIM
| ID: wpr-105756
ABSTRACT
Phospholipase C (PLC)1 hydrolyzes phosphatidylinositol 4,5-bisphosphate to generate the second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces a transient increase in intracellular free Ca2+, while DAG directly activates protein kinase C. Upon stimulation of cells with growth factors, PLC-gamma1 is activated upon their association with and phosphorylation by receptor and non-receptor tyrosine kinases. In this review, we will focus on the activation mechanism and regulatory function of PLC-gamma1.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fosfolipasas de Tipo C
/
Linfocitos T
/
Sistemas de Mensajero Secundario
/
División Celular
/
Activación Enzimática
/
Isoenzimas
Idioma:
Inglés
Revista:
Experimental & Molecular Medicine
Año:
2000
Tipo del documento:
Artículo
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