A case of acute renal failure complicated during interferon treatment of chronic hepatitis B / 대한내과학회지

ABSTRACT

Hepatitis B virus infection is known to be associated with various types of glomerulonephritis (GN), including membranous GN, membranoproliferative GN, and mesangial proliferative GN. Although there has been considerable experiences with interferon in clinical trials during the past decade, acute renal failure as a complication of interferon treatment has rarely been reported. We report a case in which acute renal failure with proteinuria was associated with interferon-alpha treatment. A 33-year-old man with chronic hepatitis B presented with diarrhea and RUQ pain. Two weeks after INF-alpha treatment, Oliguria and proteinuria suddenly occurred, although the hepatic function was improved. With discontinuation of interferon treatment and ultrafiltration, his renal function was improved.