Comparison of ramosetron's and ondansetron's preventive anti-emetic effects in highly susceptible patients undergoing abdominal hysterectomy / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 488-492, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-106334
ABSTRACT
BACKGROUND:
This study compared the preventive effects of ramosetron and ondansetron on postoperative nausea and vomiting (PONV) in highly susceptible patients undergoing abdominal hysterectomy.METHODS:
In a prospective, randomized, double-blinded study, a total of 120 highly susceptible women (nonsmokers, those receiving opioid-based IV patient-controlled analgesia [PCA]) undergoing abdominal hysterectomy were included in the study. Patients were divided into 2 groups and each group received either 0.3 mg of ramosetron or 4 mg of ondansetron, IV. All patients received fentanyl-based IV PCA during the 48 h postoperative periods. The incidences of PONV and side effects of 5-HT3 antagonists (headache and dizziness) were assessed at 3 intervals (<2 h, 2-24 h and 24-48 h) postoperatively.RESULTS:
Patients in the ramosetron group showed a significantly higher ratio of complete response and lower incidence of nausea during the 24-48 h interval after surgery compared with those the ondansetron group.CONCLUSIONS:
Ramosetron (0.3 mg) is more effective in preventing delayed PONV in highly susceptible women undergoing abdominal hysterectomy compared with ondansetron (4 mg).
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Periodo Posoperatorio
/
Bencimidazoles
/
Anafilaxis Cutánea Pasiva
/
Incidencia
/
Estudios Prospectivos
/
Analgesia Controlada por el Paciente
/
Ondansetrón
/
Náusea y Vómito Posoperatorios
/
Antagonistas del Receptor de Serotonina 5-HT3
/
Histerectomía
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Korean Journal of Anesthesiology
Año:
2011
Tipo del documento:
Artículo
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