Comparison of ramosetron's and ondansetron's preventive anti-emetic effects in highly susceptible patients undergoing abdominal hysterectomy / 대한마취과학회지
Korean Journal of Anesthesiology
; : 488-492, 2011.
Article
en En
| WPRIM
| ID: wpr-106334
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND: This study compared the preventive effects of ramosetron and ondansetron on postoperative nausea and vomiting (PONV) in highly susceptible patients undergoing abdominal hysterectomy. METHODS: In a prospective, randomized, double-blinded study, a total of 120 highly susceptible women (nonsmokers, those receiving opioid-based IV patient-controlled analgesia [PCA]) undergoing abdominal hysterectomy were included in the study. Patients were divided into 2 groups and each group received either 0.3 mg of ramosetron or 4 mg of ondansetron, IV. All patients received fentanyl-based IV PCA during the 48 h postoperative periods. The incidences of PONV and side effects of 5-HT3 antagonists (headache and dizziness) were assessed at 3 intervals (<2 h, 2-24 h and 24-48 h) postoperatively. RESULTS: Patients in the ramosetron group showed a significantly higher ratio of complete response and lower incidence of nausea during the 24-48 h interval after surgery compared with those the ondansetron group. CONCLUSIONS: Ramosetron (0.3 mg) is more effective in preventing delayed PONV in highly susceptible women undergoing abdominal hysterectomy compared with ondansetron (4 mg).
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Texto completo:
1
Índice:
WPRIM
Asunto principal:
Periodo Posoperatorio
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Bencimidazoles
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Anafilaxis Cutánea Pasiva
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Incidencia
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Estudios Prospectivos
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Analgesia Controlada por el Paciente
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Ondansetrón
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Náusea y Vómito Posoperatorios
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Antagonistas del Receptor de Serotonina 5-HT3
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Histerectomía
Tipo de estudio:
Clinical_trials
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Incidence_studies
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Observational_studies
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Prognostic_studies
Límite:
Female
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Humans
Idioma:
En
Revista:
Korean Journal of Anesthesiology
Año:
2011
Tipo del documento:
Article