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Comparison of ramosetron's and ondansetron's preventive anti-emetic effects in highly susceptible patients undergoing abdominal hysterectomy / 대한마취과학회지
Korean Journal of Anesthesiology ; : 488-492, 2011.
Artículo en Inglés | WPRIM | ID: wpr-106334
ABSTRACT

BACKGROUND:

This study compared the preventive effects of ramosetron and ondansetron on postoperative nausea and vomiting (PONV) in highly susceptible patients undergoing abdominal hysterectomy.

METHODS:

In a prospective, randomized, double-blinded study, a total of 120 highly susceptible women (nonsmokers, those receiving opioid-based IV patient-controlled analgesia [PCA]) undergoing abdominal hysterectomy were included in the study. Patients were divided into 2 groups and each group received either 0.3 mg of ramosetron or 4 mg of ondansetron, IV. All patients received fentanyl-based IV PCA during the 48 h postoperative periods. The incidences of PONV and side effects of 5-HT3 antagonists (headache and dizziness) were assessed at 3 intervals (<2 h, 2-24 h and 24-48 h) postoperatively.

RESULTS:

Patients in the ramosetron group showed a significantly higher ratio of complete response and lower incidence of nausea during the 24-48 h interval after surgery compared with those the ondansetron group.

CONCLUSIONS:

Ramosetron (0.3 mg) is more effective in preventing delayed PONV in highly susceptible women undergoing abdominal hysterectomy compared with ondansetron (4 mg).
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Periodo Posoperatorio / Bencimidazoles / Anafilaxis Cutánea Pasiva / Incidencia / Estudios Prospectivos / Analgesia Controlada por el Paciente / Ondansetrón / Náusea y Vómito Posoperatorios / Antagonistas del Receptor de Serotonina 5-HT3 / Histerectomía Tipo de estudio: Ensayo Clínico Controlado / Estudio de incidencia / Estudio observacional / Estudio pronóstico Límite: Femenino / Humanos Idioma: Inglés Revista: Korean Journal of Anesthesiology Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Periodo Posoperatorio / Bencimidazoles / Anafilaxis Cutánea Pasiva / Incidencia / Estudios Prospectivos / Analgesia Controlada por el Paciente / Ondansetrón / Náusea y Vómito Posoperatorios / Antagonistas del Receptor de Serotonina 5-HT3 / Histerectomía Tipo de estudio: Ensayo Clínico Controlado / Estudio de incidencia / Estudio observacional / Estudio pronóstico Límite: Femenino / Humanos Idioma: Inglés Revista: Korean Journal of Anesthesiology Año: 2011 Tipo del documento: Artículo