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Polymorphisms in 5-HT1Dbeta Receptor Gene and Personality Traits in a Korean Population / 신경정신의학
Journal of Korean Neuropsychiatric Association ; : 185-190, 2005.
Artículo en Coreano | WPRIM | ID: wpr-106391
ABSTRACT

OBJECTIVES:

Recently, there has been a growing enthusiasm in biological approach to personality; the identification of genes responsible for particular personality traits. The aim of this study was to investigate the association between the 5-HT1Dbeta G861C polymorphism and personality traits.

METHODS:

We recruited 218 normal subjects. The Korean version of the Temperament and Character Inventory (TCI) was used to assess personality traits. From blood samples taken from the subjects, DNA was isolated using standard techniques and the HT1Dbeta G861C polymorphism was genotyped by means of polymerase chain reaction and Homogeneous MassEXTEND method. We classified the subject into the GG, CG, and GG groups according to their genotypes. The differences in the temperament factors of the TCI between homozygote group (GG+CC genotype) and heterozygote group (CG genotype) were tested.

RESULTS:

The heterozygote group had significantly lower Harm avoidance (HA) scores and higher Self-directedness scores (SD) than the homozygote group.

CONCLUSION:

In conclusion, we found some associations between the 5-HT1Dbeta G861C polymorphism and the personality dimension HA and SD in a normal population.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Temperamento / ADN / Reacción en Cadena de la Polimerasa / Receptor de Serotonina 5-HT1B / Genotipo / Heterocigoto / Homocigoto Tipo de estudio: Estudio pronóstico Idioma: Coreano Revista: Journal of Korean Neuropsychiatric Association Año: 2005 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Temperamento / ADN / Reacción en Cadena de la Polimerasa / Receptor de Serotonina 5-HT1B / Genotipo / Heterocigoto / Homocigoto Tipo de estudio: Estudio pronóstico Idioma: Coreano Revista: Journal of Korean Neuropsychiatric Association Año: 2005 Tipo del documento: Artículo