Efficacy and Tolerability of Mirtazapine and Sertraline in Treatment of Patients with Posttraumatic Stress Disorder with Depression: A Randomized Open Label Trial / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 165-175, 2005.
Artículo
en Coreano
| WPRIM
| ID: wpr-106393
ABSTRACT
OBJECTIVES:
The aim of this study was to investigate the potential use of mirtazapine in Korean veterans diagnosed with PTSD, by comparing it with sertraline, a drug approved for use in PTSD in the USA.METHODS:
Efficacy was eveluated by Clinician Adninistered PTSD Scale (CAPS-2), the Hamilton Rating Scale for Depressin (HAMD-17) and the Clinical Global lmpresaion Scale (CGI), at baseline and week 1, 2, 6. Response was defined as a > or =30% decrease in CAPS-2 total score, a > or =50% decrease in total HAMD-17 score, and s CGI-I score<3.RESULTS:
51 patients on mirtazapine (measn age/duration of illness59.1/33.5 yrs) and 49 on sertratine (mean age/duration of illness60.6/35.6 years) completed the study. Mean daily dosage was 34.1 mg for mirtazapine and 101.5 mg for sertraline. On CAPS-2 total score more patients responded in the mirtazapine group at weak 1 (13 vs. 2%) and week 2 (51vs. 31%). At week 6 this difference was statistically significant (88 vs. 69%, p=0.039), CAPS-2 total score. HAMD-17 total score and CGI-I score decreased significantly in both groups, with no significant differences between groups on all time points. Main side effects for the rnirtazapine groupdry mouth (19.8%) and constipation (19.6%), somnolence (15.7%), weight gain (1.96%). For the sertraline groupindigestion (14.3%), palpitation (6.1%) agitation (2.0%), epigastric soreness (2.0%), insomnia (2.0%), sexual dysfunction (2.0%).CONCLUSION:
Mirtazapine appeared to be an effective and well-tolerated treatment for PTSD in Korean veterans.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Trastornos por Estrés Postraumático
/
Veteranos
/
Aumento de Peso
/
Hexametonio
/
Estreñimiento
/
Sertralina
/
Depresión
/
Dihidroergotamina
/
Trastornos del Inicio y del Mantenimiento del Sueño
/
Corea (Geográfico)
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Coreano
Revista:
Journal of Korean Neuropsychiatric Association
Año:
2005
Tipo del documento:
Artículo
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