The effect of propofol for conscious sedation during colonoscopy-A Prospective, Randomized Study / 대한내과학회지
Korean Journal of Medicine
;
: 30-38, 2005.
Artículo
en Coreano
| WPRIM
| ID: wpr-106608
ABSTRACT
BACKGROUND:
The objectives of this study were to assess propofol as sedative agents for colonoscopy in the safety and efficacy, compared with midazolam plus meperidine.METHODS:
120 patients undergoing colonoscopy in a prospective study were randomly assigned to one of three medication regimens. Patients in group A (n=42) received i.v. 25 mg of meperidine and 2.5 mg of midazolam. Patients in group B (n=41) received i.v. a median dose of 96.59 mg of propofol (range 40-180) and patients in group C (n=37) received i.v. 25 mg of meperidine and a median dose of 77.03 mg of propofol (range 40-150), administered by a nurse with endoscopist supervision. Endpoints were patient satisfaction, procedure and recovery times and complications.RESULTS:
The mean time to sedation was much faster in 2 groups using propofol (group A 152+/-105.9 sec, group B 52.9+/-46.5 sec, group C 56+/-63.7sec; p<0.001). The mean time to reach the cecum was not different among the 3 groups. There were total 3 episodes of oxygen desaturation to <90%, as one in each group, but the patients were spontaneously recovered with only increasing O2 concentration and arousal. Patients in group C expressed better overall mean satisfaction than patients in group A (p=0.049), but difference was not found between group A and group B. The amnestic effect was better in two groups using propofol than group A (p=0.017) The mean dose of propofol was lower in the patients who received propofol combined with low dose of meperidine than those with propofol only (77.03 mg vs 96.59 mg, p=0.009).CONCLUSION:
Nurse-administered propofol sedation with endoscopist supervision is believed to be safe and useful for colonoscopy with careful monitoring.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Organización y Administración
/
Oxígeno
/
Nivel de Alerta
/
Midazolam
/
Ciego
/
Propofol
/
Estudios Prospectivos
/
Sedación Consciente
/
Colonoscopía
/
Satisfacción del Paciente
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio observacional
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Año:
2005
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS