Factors affecting drug-induced liver injury: antithyroid drugs as instances
Clinical and Molecular Hepatology
;
: 237-248, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-106803
ABSTRACT
Methimazole and propylthiouracil have been used in the management of hyperthyroidism for more than half a century. However, hepatotoxicity is one of the most deleterious side effects associated with these medications. The mechanism(s) of hepatic injury induced by antithyroid agents is not fully recognized yet. Furthermore, there are no specific tools for predicting the occurrence of hepatotoxicity induced by these drugs. The purpose of this article is to give an overview on possible susceptibility factors in liver injury induced by antithyroid agents. Age, gender, metabolism characteristics, alcohol consumption, underlying diseases, immunologic mechanisms, and drug interactions are involved in enhancing antithyroid drugs-induced hepatic damage. An outline on the clinically used treatments for antithyroid drugs-induced hepatotoxicity and the potential therapeutic strategies found to be effective against this complication are also discussed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Antitiroideos
/
Enfermedad de Graves
/
Factores de Riesgo
/
Especies Reactivas de Oxígeno
/
Sustancias Protectoras
/
Modelos Animales de Enfermedad
/
Enfermedad Hepática Inducida por Sustancias y Drogas
/
Hipertiroidismo
Tipo de estudio:
Estudio de etiología
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Clinical and Molecular Hepatology
Año:
2014
Tipo del documento:
Artículo
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