Chromosomal Abnormalities in Myelodysplastic Syndrome with Near-tetraploidy: A Case Report
Laboratory Medicine Online
; : 47-50, 2012.
Article
en Ko
| WPRIM
| ID: wpr-106976
Biblioteca responsable:
WPRO
ABSTRACT
Massive hyperdiploidy and tetraploidy are rare cytogenetic abnormalities in myelocytic malignancies, especially in myelodysplastic syndrome (MDS). These abnormalities are known to be associated with leukemogenesis, leukemic transformation and poor prognosis. We report here the first case of MDS with near-tetraploid cytogenetic abnormality in Korea. A 80-yr-old male was diagnosed with refractory anemia with excess blasts-2 (RAEB-2). Bone marrow aspiration smear showed 16% of blasts, which were large sized myeloid blasts with irregular margins and cytoplasmic vacuolation. Cytogenetic analysis of bone marrow cells revealed numercal and structural cytogenetic abnormalities including near-tetraploidy in 8 of 20 metaphases: 45,XY,add(1)(p36.1),del(10)(p11.2),del(11)(q13),-12,-16,der(17)t(11;17) (q13;q21),add(20)(q13.1),+mar[8]/85~90,idemx2[cp8]/46,XY[4]. After chemotherapy with decitabine, he showed pancytopenia during follow-up period and died of sepsis 14 months after the diagnosis.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Pancitopenia
/
Pronóstico
/
Azacitidina
/
Médula Ósea
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Síndromes Mielodisplásicos
/
Anemia Refractaria
/
Células de la Médula Ósea
/
Estudios de Seguimiento
/
Aberraciones Cromosómicas
/
Sepsis
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
Ko
Revista:
Laboratory Medicine Online
Año:
2012
Tipo del documento:
Article