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Inhibitory Effects of Valdecoxib on Sodium Currents in Sensory Neurons
Journal of the Korean Neurological Association ; : 81-91, 2007.
Artículo en Coreano | WPRIM | ID: wpr-107153
ABSTRACT

BACKGROUND:

Valdecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor. It is effective in the treatment of rheumatoid arthritis, osteoarthritis, primary dysmenorrhea, and postoperative pain. Two kinds of sodium currents, tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R), are expressed in the dorsal root ganglia (DRG). Both sodium currents are implicated in the formation of normal and abnormal pain.

METHODS:

The effects of valdecoxib on sodium currents in rat DRG neurons were investigated using the whole-cell variation of the patch-clamp technique.

RESULTS:

Valdecoxib suppressed two types of sodium currents in a dose-dependent manner, without altering the activation and inactivation kinetics of either current type. It shifted the activation voltage toward a depolarizing direction and the steady-state inactivation voltage toward a hyperpolarizing direction, and suppressed resting channels to similar extents in both types of sodium currents. Valdecoxib slowed the recovery of both sodium currents from inactivation, and suppressed them in a frequency-dependent manner.

CONCLUSIONS:

The results suggest that valdecoxib may produce analgesic effects through the inhibition of sodium currents in sensory neurons as well as COX-2.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Osteoartritis / Dolor Postoperatorio / Artritis Reumatoide / Células Receptoras Sensoriales / Sodio / Tetrodotoxina / Cinética / Canales de Sodio / Grupos Diagnósticos Relacionados / Técnicas de Placa-Clamp Límite: Animales Idioma: Coreano Revista: Journal of the Korean Neurological Association Año: 2007 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Osteoartritis / Dolor Postoperatorio / Artritis Reumatoide / Células Receptoras Sensoriales / Sodio / Tetrodotoxina / Cinética / Canales de Sodio / Grupos Diagnósticos Relacionados / Técnicas de Placa-Clamp Límite: Animales Idioma: Coreano Revista: Journal of the Korean Neurological Association Año: 2007 Tipo del documento: Artículo