Inhibitory Effects of Valdecoxib on Sodium Currents in Sensory Neurons
Journal of the Korean Neurological Association
;
: 81-91, 2007.
Artículo
en Coreano
| WPRIM
| ID: wpr-107153
ABSTRACT
BACKGROUND:
Valdecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor. It is effective in the treatment of rheumatoid arthritis, osteoarthritis, primary dysmenorrhea, and postoperative pain. Two kinds of sodium currents, tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R), are expressed in the dorsal root ganglia (DRG). Both sodium currents are implicated in the formation of normal and abnormal pain.METHODS:
The effects of valdecoxib on sodium currents in rat DRG neurons were investigated using the whole-cell variation of the patch-clamp technique.RESULTS:
Valdecoxib suppressed two types of sodium currents in a dose-dependent manner, without altering the activation and inactivation kinetics of either current type. It shifted the activation voltage toward a depolarizing direction and the steady-state inactivation voltage toward a hyperpolarizing direction, and suppressed resting channels to similar extents in both types of sodium currents. Valdecoxib slowed the recovery of both sodium currents from inactivation, and suppressed them in a frequency-dependent manner.CONCLUSIONS:
The results suggest that valdecoxib may produce analgesic effects through the inhibition of sodium currents in sensory neurons as well as COX-2.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteoartritis
/
Dolor Postoperatorio
/
Artritis Reumatoide
/
Células Receptoras Sensoriales
/
Sodio
/
Tetrodotoxina
/
Cinética
/
Canales de Sodio
/
Grupos Diagnósticos Relacionados
/
Técnicas de Placa-Clamp
Límite:
Animales
Idioma:
Coreano
Revista:
Journal of the Korean Neurological Association
Año:
2007
Tipo del documento:
Artículo
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