Roles of Serotonergic and Adrenergic Receptors in the Antinociception of Selective Cyclooxygenase-2 Inhibitor in the Rat Spinal Cord
The Korean Journal of Pain
;
: 179-184, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-107272
ABSTRACT
BACKGROUND:
The analgesic mechanisms of cyclooxygenase (COX)-2 inhibitors have been explained mainly on the basis of the inhibition of prostaglandin biosynthesis. However, several lines of evidence suggest that their analgesic effects are mediated through serotonergic or adrenergic transmissions. We investigated the roles of these neurotransmitters in the antinociception of a selective COX-2 inhibitor at the spinal level.METHODS:
DUP-697, a selective COX-2 inhibitor, was delivered through an intrathecal catheter to male Sprague-Dawley rats to examine its effect on the flinching responses evoked by formalin injection into the hindpaw. Subsequently, the effects of intrathecal pretreatment with dihydroergocristine, prazosin, and yohimbine, which are serotonergic, alpha1 adrenergic and alpha2 adrenergic receptor antagonists, respectively, on the analgesia induced by DUP-697 were assessed.RESULTS:
Intrathecal DUP-697 reduced the flinching response evoked by formalin injection during phase 1 and 2. But, intrathecal dihydroergocristine, prazosin, and yohimbine had little effect on the antinociception of intrathecal DUP-697 during both phases of the formalin test.CONCLUSIONS:
Intrathecal DUP-697, a selective COX-2 inhibitor, effectively relieved inflammatory pain in rats. Either the serotonergic or adrenergic transmissions might not be involved in the analgesic activity of COX-2 inhibitors at the spinal level.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Médula Espinal
/
Tiofenos
/
Yohimbina
/
Prazosina
/
Receptores Adrenérgicos
/
Prostaglandina-Endoperóxido Sintasas
/
Ratas Sprague-Dawley
/
Neurotransmisores
/
Antagonistas Adrenérgicos
/
Dihidroergocristina
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
The Korean Journal of Pain
Año:
2011
Tipo del documento:
Artículo
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