Sole Trisomy 22 Not Associated with inv(16) in Myelodysplastic Syndrome / 이화의대지
The Ewha Medical Journal
; : 62-64, 2012.
Article
en En
| WPRIM
| ID: wpr-107396
Biblioteca responsable:
WPRO
ABSTRACT
Trisomy 22 is closely associated with inv(16) or t(16;16) and could be a marker of cryptic rearrangement of CBFB/MYH11 in acute myeloid leukemia (AML). Trisomy 22 not associated with CBFB/MYH11 rearrangement is a rare event. Here, we report a case diagnosed as refractory anemia with excess blasts-2 (RAEB-2) with sole trisomy 22 in the absence of CBFB/MYH11 rearrangement. The cytogenetic study of bone marrow cells disclosed trisomy 22 in 10% of metaphase cells analyzed. The other chromosomal abnormalities were not found. Fluorescence in situ hybridization (FISH) using CBFB/MYH11 probe to detect cryptic inv(16)(p13q22) showed negative result. We also excluded rearrangements of chromosome 5, 7, 8, 20, and ETV6 by FISH. Sole trisomy 22 not associated with inv(16) is a true entity.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Trisomía
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Síndromes Mielodisplásicos
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Cromosomas Humanos Par 5
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Cromosomas Humanos Par 22
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Anemia Refractaria
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Células de la Médula Ósea
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Leucemia Mieloide Aguda
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Aberraciones Cromosómicas
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Hibridación in Situ
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Citogenética
Idioma:
En
Revista:
The Ewha Medical Journal
Año:
2012
Tipo del documento:
Article