Clinical Reviews of Landau-Kleffner Syndrome / 대한소아신경학회지
Journal of the Korean Child Neurology Society
;
(4): 283-289, 2003.
Artículo
en Coreano
| WPRIM
| ID: wpr-107771
ABSTRACT
PURPOSE:
We intended to describe the clinical features including characteristic etiologies, therapeutic approaches and outcomes for Landau-Kleffner syndrome(LKS).METHODS:
A retrospective chart reviews were done to reveal the clinical and electrophysiological features in 5 patients who were diagnosed as LKS and undergone extensive diagnostic work-up and various therapeutic interventions.RESULTS:
Among five LKS patients, 2 patients were males and 3 were females. All patients showed well controlled seizure outcomes but cognitive function including auditory and/or expressive aphasia were not improved in spite of using various anticonvulsants. Only two patients responded to steroid therapy but one patient showed repeated deterioration after discontinuation of the durg. Among 3 patients who were on ketogenic diet(KD), one patient showed a dramatic improvement in liguistic and cognitive functions in spite of underlying mitochondrial complex I deficiency. Multiple subpial transections (MST) were done in the other two patients because of incomplete recovery from ketogenic diet, and only one patient showed fairly successful improvement.CONCLUSION:
Cognitive regression induced by LKS could be successfully improved by various therapeutic modalities including steroid, KD and palliative MST in most patients.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Afasia de Broca
/
Convulsiones
/
Estudios Retrospectivos
/
Síndrome de Landau-Kleffner
/
Dieta Cetogénica
/
Anticonvulsivantes
Tipo de estudio:
Estudio observacional
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Journal of the Korean Child Neurology Society
Año:
2003
Tipo del documento:
Artículo
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