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Prognostic Implication of Programmed Death-1-Positive Tumor-infiltrating Lymphocytes in Diffuse Large B-Cell Lymphoma
Korean Journal of Pathology ; : 573-581, 2011.
Artículo en Inglés | WPRIM | ID: wpr-107784
ABSTRACT

BACKGROUND:

Programmed death-1 (PD-1) is physiologically expressed by germinal center-associated helper T-cells and has an inhibitory effect on T-cell activity.

METHODS:

We examined 63 cases of diffuse large B-cell lymphoma (DLBCL) and determined the number of PD-1-positive helper T-cells in a representative tumor area after immunohistochemical staining using a monoclonal antibody against PD-1. The PD-1-positive cells were counted in 3 high-power fields (HPFs; 400x).

RESULTS:

Patients were divided into 2 groups one with a high number of PD-1-positive cells (>20/HPF, n=33) and one with a low number of PD-1-positive cells (< or =20/HPF, n=30). The former group showed decreased overall survival, but at a statistically non-significant level (p=0.073). A high number of PD-1-positive cells was more common in patients at an advanced clinical stage and with high international prognostic index score (p=0.025 and p=0.026, respectively). The number of extranodal sites also somewhat correlated with the PD-1 staining status (p=0.071). However, the number of PD-1-positive cells was not associated with patient age, serum lactate dehydrogenase level, and Eastern Cooperative Oncology Group performance score.

CONCLUSIONS:

The high number of PD-1-positive cells might be associated with an unfavorable outcome in DLBCL patients.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Linfocitos B / Linfocitos T / Linfocitos Infiltrantes de Tumor / Linfoma de Células B / Linfoma de Células B Grandes Difuso / Linfocitos T Colaboradores-Inductores / L-Lactato Deshidrogenasa / Linfoma Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Korean Journal of Pathology Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Linfocitos B / Linfocitos T / Linfocitos Infiltrantes de Tumor / Linfoma de Células B / Linfoma de Células B Grandes Difuso / Linfocitos T Colaboradores-Inductores / L-Lactato Deshidrogenasa / Linfoma Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Korean Journal of Pathology Año: 2011 Tipo del documento: Artículo