The Effect of 5% Imiquimod Cream on C57BL/6 Mouse Melanoma Growth / 대한피부과학회지
Korean Journal of Dermatology
;
: 1332-1336, 2005.
Artículo
en Coreano
| WPRIM
| ID: wpr-108005
ABSTRACT
BACKGOUND Imiquimod enhances both acquired and innate immune responses by inducing the synthesis of IFN-alpha and other cytokines (TNF-alpha, IL-1, 6, 8, 12, GM-CSF). Imiguimod was investigated in relation to melanoma, a highly resistant cancer in its immunogenic nature, but also an attractive target for immunotherapy. OBJECTIVE:
The purpose of this study was to investigate the anti-tumor effect of 5% imiquimod cream in vivo.METHOD:
C57BL/6 mice were inoculated intradermally into the left flank with 2X103 murine B16 melanoma cells. Five groups (including vehicle only, imiquimod cream, imiquimod cream with dimethyl sulfoxide (DMSO), vehicle with ultrasound, and imiquimod cream with ultrasound) were treated once daily at the inoculation site of the melanoma cells. The tumor growth was evaluated daily by using a caliper.RESULTS:
The difference in tumor growth was seen around day 12 of treatment, and only the group of 5% imiquimod cream with ultrasound showed a decrease in tumor growth when compared to the control group.CONCLUSION:
These results indicate that topical application of 5% imiquimod cream on mouse skin melanomas induces inhibition of tumor growth, and imiquimod cream could be used for the combination treatment of malignant melanoma.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Piel
/
Melanoma Experimental
/
Dimetilsulfóxido
/
Citocinas
/
Ultrasonografía
/
Interleucina-1
/
Inmunidad Innata
/
Inmunoterapia
/
Melanoma
Tipo de estudio:
Estudio diagnóstico
Límite:
Animales
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Año:
2005
Tipo del documento:
Artículo
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