Cytotoxicity of gamma-ray in rat immature hippocampal neurons
Journal of Veterinary Science
;
: 203-207, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-108033
ABSTRACT
This in vitro study evaluated the detrimental effect of acute gamma (gamma)-irradiation on rat immature hippocampal neurons. Rat immature hippocampal neurons (0.5 day in vitro) were irradiated with 0~4 Gy gamma-rays. Cytotoxicity was analyzed using a lactate dehydrogenase release assay at 24 h after gamma-irradiation. Radiation-induced cytotoxicity in immature hippocampal neurons increased in a dose-dependent manner. Pre-treatments of pro-apoptotic caspase inhibitors and anti-oxidative substances significantly blocked gamma-irradiation-induced cytotoxicity in immature hippocampal neurons. The results suggest that the caspase-dependent cytotoxicity of gamma-rays in immature hippocampal cultured neurons may be caused by oxidative stress.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Catequina
/
Supervivencia Celular
/
Células Cultivadas
/
Poli(ADP-Ribosa) Polimerasas
/
Ratas Sprague-Dawley
/
Amifostina
/
Relación Dosis-Respuesta en la Radiación
/
Caspasa 3
/
Rayos gamma
/
Hipocampo
Límite:
Animales
/
Embarazo
Idioma:
Inglés
Revista:
Journal of Veterinary Science
Año:
2011
Tipo del documento:
Artículo
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