Induced Pluripotent Stem Cells as a Novel Tool in Psychiatric Research
Psychiatry Investigation
;
: 8-17, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-108188
ABSTRACT
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) provides a valuable opportunity to study neurodevelopmental and neurodegenerative psychiatric diseases by offering an unlimited source for patient-specific neuronal and glial cells. The present review focuses on the recent advancements in modeling psychiatric disorders such as Phelan-McDermid syndrome, Timothy syndrome, Rett syndrome, schizophrenia, bipolar disorder, and dementia. The treatment effects identified in studies on iPSCs using known therapeutic compounds are also summarized in this review. Here we discuss validation of cellular models and explore iPSCs as a novel drug screening tool. Although there are several limitations associated with the current methods used to study mental disorders, using iPSCs as a model system provides the advantage of rewinding and reviewing the development and degeneration of human neural cells.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Esquizofrenia
/
Trastorno Bipolar
/
Síndrome de Rett
/
Neuroglía
/
Demencia
/
Evaluación Preclínica de Medicamentos
/
Células Madre Pluripotentes Inducidas
/
Trastornos Mentales
/
Neuronas
Tipo de estudio:
Estudio diagnóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Psychiatry Investigation
Año:
2016
Tipo del documento:
Artículo
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