The Efficacy of Peeling with Amino Acid Filaggrin Based Antioxidants(AFAs) / 대한피부과학회지

ABSTRACT

BACKGROUND: Amino acid Filaggrin based Antioxidants(AFAs) is a recently invented peeling agent and the clinical report of the effects of AFAs peeling is insufficient. OBJECTIVE: The purpose of this study was to investigate the efficacy of peeling with AFAs. METHODS: This is a retrospective case study for the 41 patients treated with AFAs peeling at Sanggye Paik Hospital between January, 2002 to April, 2003. The therapeutic efficay was evaluated by the degree of satisfaction of both the patients and practitioners, regarding the number of peelings and the concentration of AFAs. Adverse effects were also evaluated. RESULTS: The results of this study were as follows. Of the 41 patients, 20 were acne, 14 were melasma, 4 were freckle, 2 were postinflammatory hyperpigmentation, and the other was an acne scar patient. The satisfaction rates of the patients were excellent(> or =70% improved) 17, good(50-70%) 11, fair(30-50%) 8, and poor(<30%) 5 out of 41 cases. And those of the practitioners were respectively 18, 14, 4, and 5 out of 41 cases. The satisfaction rates tended to increase as the number of peelings increased, while the concentration of AFAs showed little relation with the therapeutic effect. 4. The adverse effects were immediate vesiculation probably due to allergic reaction(3/41), persistent erythema(2/41), persistent irritation(2/41), pigmentation(1/41), and tingling sensation(1/41). CONCLUSION: AFAs peeling is an effective treatment modality in Korea and several repeelings improve the therapeutic effect. But futher studies on the adverse effects of this procedure are necessary.