Pro- and anti-inflammatory cytokine expression and histopathological characteristics in canine brain with traumatic brain injury
Journal of Veterinary Science
; : 299-301, 2011.
Article
en En
| WPRIM
| ID: wpr-108421
Biblioteca responsable:
WPRO
ABSTRACT
We analyzed the expression level and cellular localization of pro- and anti-inflammatory cytokines and histopathologically characterized canine traumatic brain injury (TBI). Canine TBI brains revealed subarachnoid and cerebral cortical hemorrhage, neutrophilic infiltration, neuronal necrosis, astrocytosis, and vasogenic edema. Immunohistochemical evaluations suggested that both pro-inflammatory cytokines [interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha] and anti-inflammatory cytokines [IL-10 and transforming growth factor-beta (TGF-beta)] were highly expressed in neurons and neutrophils. In particular, the highest magnitude of expression was identified for IL-1beta and TGF-beta. This data helps describe the pathologic characteristics of canine TBI, and may help in the design of potential therapeutic approaches to control secondary damage by inflammatory cytokines.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Encéfalo
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Lesiones Encefálicas
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Factor de Crecimiento Transformador beta
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Interleucina-6
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Factor de Necrosis Tumoral alfa
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Interleucina-10
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Interleucina-1beta
Tipo de estudio:
Prognostic_studies
Límite:
Animals
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Humans
Idioma:
En
Revista:
Journal of Veterinary Science
Año:
2011
Tipo del documento:
Article