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The Effect of Immunoglobulin as Adjuvant Therapy in Pediatric Patients with Antibiotic Ineffective Pneumonia / 소아알레르기및호흡기학회지
Pediatric Allergy and Respiratory Disease ; : 17-22, 2010.
Artículo en Coreano | WPRIM | ID: wpr-109329
ABSTRACT

PURPOSE:

Despite the appropriate antibiotic therapy, some patients with pneumonia do not show a significant clinical improvement. One of the important factors associated with the aggravation of pneumonia is the inflammatory response of the patient. The use of intravenous immunoglobulin (IVIG) to regulate inflammation in severe pneumonia may be beneficial. We evaluated the therapeutic effect of IVIG as an add-on therapy in patients whose pneumonia did not respond to the initial antibiotic therapy.

METHODS:

This study was conducted from January 2006 to March 2009 on 14 patients admitted with pneumonia who showed persistent fever and progressive worsening of radiographic findings in spite of appropriate empirical antibiotic therapy. Immunoglobulin was administrated on the 3rd to 10th admission days (6th days on average).

RESULTS:

The median age was 67 months (range 16-102 months), and 8 were female. All children received ampicillin+sulbactam+macrolide, or cefotaxime+macrolide. Acute Mycoplasma infection occurred in 64% (9/14) of the patients. The collapse and/or consolidation of the lobe was found in 50% (7/14) of the patients on chest radiograph. After IVIG administration, all patients became afebrile within 24 hrs, and their C-reactive protein and radiographic findings showed a significant improvement in several days.

CONCLUSION:

Prompt IVIG therapy may be beneficial to patients with pneumonia who did not respond to the initial antibiotic therapy, especially when the use of corticosteroids is contraindicated.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neumonía / Tórax / Proteína C-Reactiva / Inmunoglobulina A / Inmunoglobulinas / Inmunoglobulinas Intravenosas / Corticoesteroides / Fiebre / Inflamación / Infecciones por Mycoplasma Límite: Niño / Femenino / Humanos Idioma: Coreano Revista: Pediatric Allergy and Respiratory Disease Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neumonía / Tórax / Proteína C-Reactiva / Inmunoglobulina A / Inmunoglobulinas / Inmunoglobulinas Intravenosas / Corticoesteroides / Fiebre / Inflamación / Infecciones por Mycoplasma Límite: Niño / Femenino / Humanos Idioma: Coreano Revista: Pediatric Allergy and Respiratory Disease Año: 2010 Tipo del documento: Artículo