Fasting Serum Glucose and Subsequent Liver Cancer Risk in a Korean Prospective Cohort / 예방의학회지
Journal of Preventive Medicine and Public Health
;
: 23-28, 2007.
Artículo
en Coreano
| WPRIM
| ID: wpr-10941
ABSTRACT
OBJECTIVES:
Chronic infections with hepatitis B or C and alcoholic cirrhosis are three well-known major risk factors for liver cancer. Diabetes has also been suggested as a potential risk factor. However, the findings of previous studies have been controversial in terms of the causal association. Therefore, the aim of this study was to evaluate the association between serum glucose levels and liver cancer development in a Korean cohort.METHODS:
Thirty-six liver cancer cases were identified in the Korean Multi-Center Cancer Cohort (KMCC). Baseline information on lifestyle characteristics was obtained via questionnaire. Serum glucose levels were measured at the study's enrollment. Relative risks (RRs) were estimated using a Cox proportional hazard regression model. The adjusting variables included age, gender, smoking history, alcohol consumption, body mass index, and hepatitis B surface antigen (HBsAg) seropositivity.RESULTS:
The RRs of serum glucose for liver caner were 1.20 (95% CI=0.48-2.99) for the category of 100 to 125 mg/dL of serum glucose and 2.77 (95% CI=1.24-6.18) for the >126 mg/dL serum glucose category (both compared to the 100 mg/dL.CONCLUSIONS:
The results of this study suggest that a high level of serum glucose can increase liver cancer risk independently of hepatitis infection and drinking history in Koreans. This study implies that glucose intolerance may be an independent risk factor for liver cancer.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Glucemia
/
Consumo de Bebidas Alcohólicas
/
Modelos de Riesgos Proporcionales
/
Virus de la Hepatitis B
/
Factores de Riesgo
/
Estudios de Cohortes
/
Ayuno
/
Hepatitis B
/
Antígenos de Superficie de la Hepatitis B
/
Corea (Geográfico)
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Coreano
Revista:
Journal of Preventive Medicine and Public Health
Año:
2007
Tipo del documento:
Artículo
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