Immunological disorder in patients with acquired bone marrow failure with unknown causes

ABSTRACT

The study was carried out in 65 aplastic anemia patients admitted into B¹ch Mai hospital during the period 1995-1999 on the issues of immunological characteristics. The results can be summarized as follows The count of lymphocytes and the majority of sub-groups of lymphocytes were decreased compared with the control group (p<0.05 - 0.01). The TCD4/TCD8 ratio is decrease compared with the control group. The level of IgG in plasma increased. In the bone marrow, the count of subgroup of lymphocytes decreased compared with the control group. Comparing between peripheral blood and bone marrow, it can be seen that the percentage of T lymphocytes and its sub-groups decreased significantly. The change of the percentage of B lymphocytes however, it is not significant.