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Prognostic Scoring Index for Patients with Metastatic Pancreatic Adenocarcinoma / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 1253-1263, 2016.
Artículo en Inglés | WPRIM | ID: wpr-109751
ABSTRACT

PURPOSE:

This study focused on implementation of a prognostic scoring index based on clinico-laboratory parameters measured routinely on admission in metastatic pancreatic cancer patients. MATERIALS AND

METHODS:

Records from 403 patients of metastatic disease were analyzed retrospectively. Continuous variables were dichotomized according to the normal range or the best cut-off values statistically determined by Contal and O’Quigley method, and then analyzed in association with prognosis—overall survival (OS), using Cox's proportional hazard model. Scores were calculated by summing the rounded chi-square scores for the factors that emerged in the multivariate analysis.

RESULTS:

Performance status, hemoglobin, leucocyte count, neutrophil-lymphocyte ratio, and carcinoembryonic antigen were independent factors for OS. When patients were divided into three risk groups according to these factors, median survival was 11.7, 6.2, and 1.3 months for the low, intermediate, and high-risk groups, respectively (p < 0.001). Palliative chemotherapy has a significant survival benefit for low and intermediate-risk patients (median OS; 12.5 months vs. 5.9 months, p < 0.001 and 8.0 months vs. 2.0 months, p < 0.001, respectively).

CONCLUSION:

We advocate the use of a multivariable approach with continuous variables for prognostic modeling. Our index is helpful in accurate patient risk stratification and may aid in treatment selection.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Pancreáticas / Pronóstico / Valores de Referencia / Proyectos de Investigación / Adenocarcinoma / Antígeno Carcinoembrionario / Modelos de Riesgos Proporcionales / Análisis Multivariante / Estudios Retrospectivos / Quimioterapia Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Humanos Idioma: Inglés Revista: Cancer Research and Treatment Año: 2016 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Pancreáticas / Pronóstico / Valores de Referencia / Proyectos de Investigación / Adenocarcinoma / Antígeno Carcinoembrionario / Modelos de Riesgos Proporcionales / Análisis Multivariante / Estudios Retrospectivos / Quimioterapia Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Humanos Idioma: Inglés Revista: Cancer Research and Treatment Año: 2016 Tipo del documento: Artículo