Granulocyte Colony Stimulating Factor (G-CSF) Attenuates 2,4,6-Trinitrobenzene Sulfonic Acid (TNBS)-induced Colitis in Mice
Immune Network
;
: 13-19, 2006.
Artículo
en Coreano
| WPRIM
| ID: wpr-109770
ABSTRACT
BACKGROUND:
Granulocyte colony stimulating factor (G-CSF) is known as a cytokine central to the hematopoiesis of blood cells and to modulate their cellular functions. Besides granulocytes and their precursors, monocytes/macrophages and endothelial cells are direct target cells of G-CSF action. G-CSF influences immune cells in an anti-inflammatory way.METHODS:
To evaluate whether G-CSF has a potential for preventing or ameliorating diseases characterized by mucosal inflammation, we used a mouse model with trinitrobenzene sulfonic acid (TNBS)-induced inflammatory colitis. To the mice model G-CSF was administrated daily by intraperitoneal injection. Macroscopic evaluation and immunohistochemical analysis of colonic tissues were performed.RESULTS:
Recombinant human G-CSF significantly inhibited LPS-induced TNF-alpha mRNA expression in THP-1 cells. As for in vivo relevance, G-CSF dramatically reduced the weight loss of mice, colonic damage, and mucosal ulceration that characterize TNBS colitis. Moreover, G-CSF suppressed the expression of tumor necrosis factor-alpha, interleukin-1beta, and intercellular adhesion molecule-1 in TNBS colitis.CONCLUSION:
Current results demonstrate that G-CSF may be an effective agent for the treatment of diseases characterized by mucosal inflammation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Úlcera
/
Células Sanguíneas
/
ARN Mensajero
/
Enfermedades Inflamatorias del Intestino
/
Pérdida de Peso
/
Factor Estimulante de Colonias de Granulocitos
/
Factores Estimulantes de Colonias
/
Factor de Necrosis Tumoral alfa
/
Colitis
/
Colon
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Humanos
Idioma:
Coreano
Revista:
Immune Network
Año:
2006
Tipo del documento:
Artículo
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