Relationships between Serum Adiponectin with Metabolic Syndrome and Components of Metabolic Syndrome in Non-Diabetic Koreans: ARIRANG Study
Yonsei Medical Journal
;
: 234-241, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-110479
ABSTRACT
PURPOSE:
Growing evidence suggests that hypoadiponectinemia may play a significant role in the development of metabolic syndrome (MetS). Therefore, the relationships between serum adiponectin with MetS and components of MetS were investigated in non-diabetic samples of drawn from the Koreans general population. MATERIALS ANDMETHODS:
We performed a cross-sectional study in samples of older Koreans (age > 40 years) including 2,471 men and 3,463 women. MetS was defined according to the Asian modified criteria of the National Cholesterol Education Program Adult Treatment Panel III report. Serum adiponectin concentrations were measured by radioimmunoassay.RESULTS:
The median adiponectin level in MetS was significantly lower than that in non-MetS subjects in men (6.00 vs. 8.00 microg/mL, p < 0.001) and women (10.12 vs. 11.74 microg/mL, p < 0.001). Adiponectin concentration was negatively correlated with waist circumference and levels of triglyceride, C-reactive protein (CRP), fasting glucose, and insulin, and positively correlated with high-density lipoprotein and age in both genders (p < 0.001). In a multivariate regression model after adjustment for age, body mass index, smoking, CRP, and lipid profiles, the odds ratio of MetS comparing extreme quartiles of adiponectin distribution was 0.32 [95% confidence interval (CI), 0.20 to 0.50] in men and 0.57 (95% CI, 0.43 to 0.76) in women.CONCLUSION:
Adiponectin levels are independently associated with the phenotype of MetS, as well as components of MetS in the non-diabetic Korean general population.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Razón de Masculinidad
/
Triglicéridos
/
Glucemia
/
Proteína C-Reactiva
/
Índice de Masa Corporal
/
Oportunidad Relativa
/
Estudios Transversales
/
Análisis Multivariante
/
Síndrome Metabólico
/
Adiponectina
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio de prevalencia
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Yonsei Medical Journal
Año:
2011
Tipo del documento:
Artículo
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