Occupational asthma induced by cephalosporin precursor / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
;
: 90-94, 2003.
Artículo
en Coreano
| WPRIM
| ID: wpr-110740
ABSTRACT
A 41-year-old male pharmaceutical worker developed dyspnea and wheezing 10 years after beginning the work. He had handled powder of cephalosporin precursor, 7-aminocephalosporanic acid (7-ACA). He had suffered from dyspnea, chest tightness and wheezing in the workplace for the last three years. Recently, these symptoms were aggravated. His pulmonary function test showed severe obstructive pattern and PC(20) was 0.06 mg/ml on MBPT(methacholine bronchial provocation test). Skin prick test and intradermal test showed positive reactions to ceftriaxone, cefazolin, etc. During the skin test, he suffered from an asthmatic attack and anaphylactic shock. Bronchial provocation test with cefotiam elicited a dual asthmatic reaction. We presumed that IgE-mediated mechanism may be mainly involved in the pathogenesis of cephalosporin induced occupational asthma, in addition to other immunologic or non-immunologic mechanisms. Further studies will be necessary to investigate the pathogenesis of this disease.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pruebas de Función Respiratoria
/
Piel
/
Tórax
/
Ceftriaxona
/
Pruebas de Provocación Bronquial
/
Pruebas Intradérmicas
/
Pruebas Cutáneas
/
Cefotiam
/
Cefazolina
/
Ruidos Respiratorios
Límite:
Adulto
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Journal of Asthma, Allergy and Clinical Immunology
Año:
2003
Tipo del documento:
Artículo
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