Expression of neurotrophic factors in injured spinal cord after transplantation of human-umbilical cord blood stem cells in rats
Journal of Veterinary Science
;
: 97-102, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-110760
ABSTRACT
We induced percutaneous spinal cord injuries (SCI) using a balloon catheter in 45 rats and transplanted human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) at the injury site. Locomotor function was significantly improved in hUCB-MSCs transplanted groups. Quantitative ELISA of extract from entire injured spinal cord showed increased expression of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin-3 (NT-3). Our results show that treatment of SCI with hUCB-MSCs can improve locomotor functions, and suggest that increased levels of BDNF, NGF and NT-3 in the injured spinal cord were the main therapeutic effect.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Traumatismos de la Médula Espinal
/
Ensayo de Inmunoadsorción Enzimática
/
Regulación de la Expresión Génica
/
Factor Neurotrófico Derivado del Encéfalo
/
Factor de Crecimiento Nervioso
/
Perfilación de la Expresión Génica
/
Trasplante de Células Madre de Sangre del Cordón Umbilical
/
Locomoción
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Journal of Veterinary Science
Año:
2016
Tipo del documento:
Artículo
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