Drug-Induced Liver Injury: Pattern Recognition and Future Directions
Gut and Liver
;
: 27-36, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-111621
ABSTRACT
Drug-induced liver injury (DILI) remains a significant clinical challenge and is the leading cause of acute liver failure in most countries. An aging population that uses more medications, a constant influx of newly developed drugs and a growing risk from unfamiliar herbal and dietary supplements will make DILI an increasing part of clinical practice. Currently, the most effective strategy for disease management is rapid identification, withholding the inciting agents, supportive care and having a firm understanding of the expected natural history. There are resources available to aid the clinician, including a new online "textbook" as well as causality assessment tools, but a heightened awareness of risk and the disease's varying phenotypes and good history-taking remain cornerstones to diagnosis. Looking ahead, growing registries of cases, pharmacoepidemiology studies and translational research into the mechanisms of injury may produce better diagnostic tools, markers for risk and disease, and prevention and therapeutics.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Biopsia
/
Medicamentos Herbarios Chinos
/
Antiinflamatorios no Esteroideos
/
Incidencia
/
Factores de Riesgo
/
Factores de Edad
/
Factor de Necrosis Tumoral alfa
/
Inhibidores de Hidroximetilglutaril-CoA Reductasas
/
Suplementos Dietéticos
/
Enfermedad Hepática Inducida por Sustancias y Drogas
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
Idioma:
Inglés
Revista:
Gut and Liver
Año:
2016
Tipo del documento:
Artículo
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