A Case of Hemophagocytic Lymphohistiocytosis with Clonal Karyotype Abnormalities
Laboratory Medicine Online
;
: 110-114, 2011.
Artículo
en Coreano
| WPRIM
| ID: wpr-111801
ABSTRACT
There have been a few reports of hemophagocytic lymphohistiocytosis (HLH) with chromosomal abnormalities. Clonal chromosomal abnormalities in HLH patients are usually found in association with hematologic malignancies and rarely with epstein-barr virus (EBV) infection. Here, we report a fatal case of HLH with clonal karyotype abnormalities. A 75-yr-old man was admitted with persistent anorexia and high fever. Laboratory data revealed pancytopenia, hypofibrinogenemia, hyperferritinemia, prolonged prothrombin time and activated partial thromboplastin time, and marked elevated level of serum transaminases. In real time-PCR using whole blood, EBV DNA was not detected but cytomegalovirus (CMV) DNA was detected. The bone marrow aspiration smear showed hyperplasia of mature histiocytes with prominent hemophagocytosis. In chromosomal analysis of bone marrow aspirates, complex chromosomal abnormalities were found. In spite of steroid pulse therapy and antibiotic treatment, he died of disseminated intravascular coagulopathy.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pancitopenia
/
Tiempo de Tromboplastina Parcial
/
Tiempo de Protrombina
/
Médula Ósea
/
ADN
/
Anorexia
/
Aberraciones Cromosómicas
/
Herpesvirus Humano 4
/
Neoplasias Hematológicas
/
Citomegalovirus
Límite:
Humanos
Idioma:
Coreano
Revista:
Laboratory Medicine Online
Año:
2011
Tipo del documento:
Artículo
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