Association between Metformin Therapy and Breast Cancer Incidence and Mortality: Evidence from a Meta-Analysis / 한국유방암학회지
Journal of Breast Cancer
;
: 264-270, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-112050
ABSTRACT
PURPOSE:
Metformin may be associated with a decreased risk of breast cancer. We performed a meta-analysis to assess the effect of metformin intake on breast cancer risk and mortality.METHODS:
We performed a PubMed and EMbase search for all available studies that described the risk of breast cancer and all-cause mortality in relation to the use of metformin among patients with type 2 diabetes mellitus. Pooled relative risks (RRs) were determined using a random effects model to assess the strength of association between metformin and the risk of breast cancer.RESULTS:
Fifteen articles from PubMed satisfied the inclusion criteria, including a total of 838,333 participants. Compared with the control group, metformin use was not related to a reduced incidence of breast cancer (RR, 0.964; 95% confidence interval [CI], 0.761-1.221; p=0.761). However, metformin therapy was associated with decreased all-cause mortality (RR, 0.652; 95% CI, 0.488-0.873; p=0.004). No obvious publication bias was detected (incidence p(Begg)=0.755, p(Egger)=0.008; mortality p(Begg)=0.072, p(Egger)=0.185).CONCLUSION:
The present study suggested that metformin therapy may decrease the all-cause mortality of patients affected by breast cancer. However, this finding should be considered carefully and confirmed with further studies.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Mama
/
Neoplasias de la Mama
/
Incidencia
/
Mortalidad
/
Sesgo de Publicación
/
Medición de Riesgo
/
Diabetes Mellitus Tipo 2
/
Metformina
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio pronóstico
/
Factores de riesgo
/
Revisiones Sistemáticas Evaluadas
Límite:
Humanos
Idioma:
Inglés
Revista:
Journal of Breast Cancer
Año:
2015
Tipo del documento:
Artículo
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